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Structure paper

TitleStructural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
Journal, issue, pagesJ. Exp. Med., Vol. 204, Page 2277-, Year 2007
Publish dateMar 22, 2007 (structure data deposition date)
AuthorsProsser, B.E. / Johnson, S. / Roversi, P. / Herbert, A.P. / Blaum, B.S. / Tyrrell, J. / Jowitt, T.A. / Clark, S.J. / Tarelli, E. / Uhrin, D. ...Prosser, B.E. / Johnson, S. / Roversi, P. / Herbert, A.P. / Blaum, B.S. / Tyrrell, J. / Jowitt, T.A. / Clark, S.J. / Tarelli, E. / Uhrin, D. / Barlow, P.N. / Sim, R.B. / Day, A.J. / Lea, S.M.
External linksJ. Exp. Med. / PubMed:17893204
MethodsX-ray diffraction
Resolution2.35 - 2.5 Å
Structure data

PDB-2uwn:
Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand.
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-2v8e:
Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand.
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-CL:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ALTERNATIVE SPLICING / SUCROSE OCTASULPHATE / AGE-RELATED MACULAR DEGENERATION / COMPLEMENT ALTERNATE PATHWAY / DISEASE MUTATION / GLYCOSAMINOGLYCAN / GLYCOPROTEIN / INNATE IMMUNITY / IMMUNE RESPONSE / SUSHI / FACTOR H / COMPLEMENT / POLYMORPHISM / SECRETED

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