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-Structure paper
| Title | 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 50, Page 5090-5102, Year 2007 |
| Publish date | Mar 14, 2007 (structure data deposition date) |
 Authors | Spicer, J.A. / Rewcastle, G.W. / Kaufman, M.D. / Black, S.L. / Plummer, M.S. / Denny, W.A. / Quin, J. / Shahripour, A.B. / Barrett, S.D. / Whitehead, C.E. ...Spicer, J.A. / Rewcastle, G.W. / Kaufman, M.D. / Black, S.L. / Plummer, M.S. / Denny, W.A. / Quin, J. / Shahripour, A.B. / Barrett, S.D. / Whitehead, C.E. / Milbank, J.B. / Ohren, J.F. / Gowan, R.C. / Omer, C. / Camp, H.S. / Esmaeil, N. / Moore, K. / Sebolt-Leopold, J.S. / Pryzbranowski, S. / Merriman, R.L. / Ortwine, D.F. / Warmus, J.S. / Flamme, C.M. / Pavlovsky, A.G. / Tecle, H. |
 External links | J. Med. Chem. / PubMed:17880056 |
| Methods | X-ray diffraction |
| Resolution | 2.8 Å |
| Structure data |  PDB-2p55: |
| Chemicals |  ChemComp-MG:  ChemComp-MRA:  ChemComp-ATP:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE / protein kinase structure; Mitogen activated protein kinase kinase; signal transduction; ligand co-complex / ternary co-complex with kinase / ligand and MgATP; non-competitive protein kinase inhibitor |
homo sapiens (human)