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-Structure paper
Title | Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 17, Page 5934-5939, Year 2007 |
Publish date | Jul 20, 2007 (structure data deposition date) |
Authors | Kowalchick, J.E. / Leiting, B. / Pryor, K.D. / Marsilio, F. / Wu, J.K. / He, H. / Lyons, K.A. / Eiermann, G.J. / Petrov, A. / Scapin, G. ...Kowalchick, J.E. / Leiting, B. / Pryor, K.D. / Marsilio, F. / Wu, J.K. / He, H. / Lyons, K.A. / Eiermann, G.J. / Petrov, A. / Scapin, G. / Patel, R.A. / Thornberry, N.A. / Weber, A.E. / Kim, D. |
External links | Bioorg. Med. Chem. Lett. / PubMed:17827003 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-2qoe: |
Chemicals | ChemComp-NAG: ChemComp-NA: ChemComp-448: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / alpha/beta inhibitors / beta-propeller / dimer / diabetes / Aminopeptidase / Glycoprotein / Membrane / Protease / Secreted / Serine protease / Signal-anchor / Transmembrane |