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TitleDesign, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 5934-5939, Year 2007
Publish dateJul 20, 2007 (structure data deposition date)
AuthorsKowalchick, J.E. / Leiting, B. / Pryor, K.D. / Marsilio, F. / Wu, J.K. / He, H. / Lyons, K.A. / Eiermann, G.J. / Petrov, A. / Scapin, G. ...Kowalchick, J.E. / Leiting, B. / Pryor, K.D. / Marsilio, F. / Wu, J.K. / He, H. / Lyons, K.A. / Eiermann, G.J. / Petrov, A. / Scapin, G. / Patel, R.A. / Thornberry, N.A. / Weber, A.E. / Kim, D.
External linksBioorg. Med. Chem. Lett. / PubMed:17827003
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-2qoe:
Human Dipeptidyl Peptidase IV in complex with a Triazolopiperazine-based beta amino acid Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-NA:
Unknown entry

ChemComp-448:
(2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / alpha/beta inhibitors / beta-propeller / dimer / diabetes / Aminopeptidase / Glycoprotein / Membrane / Protease / Secreted / Serine protease / Signal-anchor / Transmembrane

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