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Structure paper

TitleStructural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.
Journal, issue, pagesMol. Endocrinol., Vol. 21, Page 2919-2928, Year 2007
Publish dateApr 13, 2007 (structure data deposition date)
AuthorsEstebanez-Perpina, E. / Arnold, L.A. / Jouravel, N. / Togashi, M. / Blethrow, J. / Mar, E. / Nguyen, P. / Phillips, K.J. / Baxter, J.D. / Webb, P. ...Estebanez-Perpina, E. / Arnold, L.A. / Jouravel, N. / Togashi, M. / Blethrow, J. / Mar, E. / Nguyen, P. / Phillips, K.J. / Baxter, J.D. / Webb, P. / Guy, R.K. / Fletterick, R.J.
External linksMol. Endocrinol. / PubMed:17823305
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-2pin:
Thyroid receptor beta in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-4HY:
[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID / hormone*YM

ChemComp-LEG:
1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE RECEPTOR / thyroid receptor beta / nuclear receptors / inhibitors / protein-protein interactions / coregulator binding / AF-2 pocket / aromatic-beta-amino ketones / structure-based drug design / surface interacting drugs

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