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-Structure paper
Title | Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. |
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Journal, issue, pages | Biochem. J., Vol. 408, Page 193-201, Year 2007 |
Publish date | Aug 15, 2007 (structure data deposition date) |
Authors | Wang, H. / Peng, M.S. / Chen, Y. / Geng, J. / Robinson, H. / Houslay, M.D. / Cai, J. / Ke, H. |
External links | Biochem. J. / PubMed:17727341 |
Methods | X-ray diffraction |
Resolution | 1.57 - 2.1 Å |
Structure data | PDB-2qyk: PDB-2qyl: PDB-2qym: PDB-2qyn: |
Chemicals | ChemComp-NPV: ChemComp-ZN: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / PDE4 inhibitor / subfamily inhibitor selectivity / PDE4B structure / selective inhibitor NVP / PDE4C structure / PDE4D selective inhibitor NVP / Alternative splicing / cAMP / Cytoplasm / Cytoskeleton / Membrane / Metal-binding / Phosphorylation |