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TitleCrystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity
Journal, issue, pagesChemmedchem, Vol. 2, Page 1631-1638, Year 2007
Publish dateMay 13, 2007 (structure data deposition date)
AuthorsKondo, J. / Pachamuthu, K. / Francois, B. / Szychowski, J. / Hanessian, S. / Westhof, E.
External linksChemmedchem / PubMed:17722211
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-2pwt:
Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-LHA:
DOUBLY FUNCTIONALIZED PAROMOMYCIN PM-II-162

ChemComp-HOH:
WATER

KeywordsRNA/ANTIBIOTIC / aminoglycoside; haba group; ribosomal decoding site; X-ray analysis; RNA / RNA-ANTIBIOTIC complex

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