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-Structure paper
Title | Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex |
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Journal, issue, pages | Embo Rep., Vol. 8, Page 879-, Year 2007 |
Publish date | Jul 10, 2007 (structure data deposition date) |
Authors | Vannini, A. / Volpari, C. / Gallinari, P. / Jones, P. / Mattu, M. / Carfi, A. / Defrancesco, R. / Steinkuhler, C. / Di Marco, S. |
External links | Embo Rep. / PubMed:17721440 |
Methods | X-ray diffraction |
Resolution | 2 - 2.25 Å |
Structure data | PDB-2v5w: PDB-2v5x: |
Chemicals | ChemComp-K: ChemComp-ZN: ChemComp-HOH: ChemComp-V5X: |
Source |
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Keywords | HYDROLASE/HYDROLASE SUBSTRATE / HISTONE DEACETYLASE / CHROMATIN REGULATOR / P53 / HDAC / HDAC8 / NUCLEUS / REPRESSOR / HYDROLASE / NUCLEAR PROTEIN / PEPTIDIC SUBSTRATE / TRANSCRIPTION REGULATION / CHROMATIN / TRANSCRIPTION / DEACETYLATION / HYDROLASE-HYDROLASE SUBSTRATE COMPLEX / HYDROXAMATE INHIBITOR / DRUG DESIGN |