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Title | Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 50, Page 4351-4373, Year 2007 |
Publish date | Aug 3, 2007 (structure data deposition date) |
![]() | Potashman, M.H. / Bready, J. / Coxon, A. / Demelfi, T.M. / Dipietro, L. / Doerr, N. / Elbaum, D. / Estrada, J. / Gallant, P. / Germain, J. ...Potashman, M.H. / Bready, J. / Coxon, A. / Demelfi, T.M. / Dipietro, L. / Doerr, N. / Elbaum, D. / Estrada, J. / Gallant, P. / Germain, J. / Gu, Y. / Harmange, J.C. / Kaufman, S.A. / Kendall, R. / Kim, J.L. / Kumar, G.N. / Long, A.M. / Neervannan, S. / Patel, V.F. / Polverino, A. / Rose, P. / Plas, S.V. / Whittington, D. / Zanon, R. / Zhao, H. |
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Methods | X-ray diffraction |
Resolution | 2.1 - 2.95 Å |
Structure data | ![]() PDB-2qu5: ![]() PDB-2qu6: |
Chemicals | ![]() ChemComp-276: ![]() ChemComp-HOH: ![]() ChemComp-SO4: ![]() ChemComp-857: |
Source |
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![]() | TRANSFERASE / receptor tyrosinse kinase / KDR / Angiogenesis / ATP-binding / Developmental protein / Differentiation / Glycoprotein / Host-virus interaction / Immunoglobulin domain / Membrane / Nucleotide-binding / Phosphorylation / Polymorphism / Transmembrane / Tyrosine-protein kinase / receptor tyrosine kinase |