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TitleLeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Journal, issue, pagesScience, Vol. 317, Page 1390-1393, Year 2007
Publish dateJul 9, 2007 (structure data deposition date)
AuthorsZhou, Z. / Zhen, J. / Karpowich, N.K. / Goetz, R.M. / Law, C.J. / Reith, M.E. / Wang, D.N.
External linksScience / PubMed:17690258
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-2qju:
Crystal Structure of an NSS Homolog with Bound Antidepressant
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-LEU:
LEUCINE

ChemComp-DSM:
3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE / antidepressant, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • aquifex aeolicus (bacteria)
KeywordsTRANSPORT PROTEIN / neurotransmitter / transmembrane transport / integral membrane protein / antidepressant / NSS / Structural Genomics / PSI-2 / Protein Structure Initiative / New York Consortium on Membrane Protein Structure / NYCOMPS

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