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Structure paper

TitleO-Aryloxycarbonyl Hydroxamates: New beta-Lactamase Inhibitors That Cross-Link the Active Site.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 129, Page 9548-9549, Year 2007
Publish dateMar 26, 2007 (structure data deposition date)
AuthorsWyrembak, P.N. / Babaoglu, K. / Pelto, R.B. / Shoichet, B.K. / Pratt, R.F.
External linksJ. Am. Chem. Soc. / PubMed:17628063
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-2p9v:
Structure of AmpC beta-lactamase with cross-linked active site after exposure to small molecule inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / beta-lactamase / cross-link

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