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TitleMechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit.
Journal, issue, pagesScience, Vol. 317, Page 239-, Year 2007
Publish dateMay 30, 2007 (structure data deposition date)
AuthorsMiled, N. / Yan, Y. / Hon, W.C. / Perisic, O. / Zvelebil, M. / Inbar, Y. / Schneidman-Duhovny, D. / Wolfson, H.J. / Backer, J.M. / Williams, R.L.
External linksScience / PubMed:17626883
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-2v1y:
Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex with the iSH2 domain from p85 alpha
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • bos taurus (domestic cattle)
  • homo sapiens (human)
KeywordsTRANSFERASE / KINASE / CANCER / SH2 DOMAIN / SH3 DOMAIN / ONCOGENIC MUTATIONS / HOST-VIRUS INTERACTION / PHOSPHORYLATION / DISEASE MUTATION / PHOSPHOINOSITIDE / PHOSPHOLIPID / PHOSPHOLIPID SIGNALLING / PHOSPHOINOSITIDE 3-KINASE / SIGNAL TRANSDUCTION

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