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Structure paper

TitleStructure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 25453-, Year 2007
Publish dateDec 11, 2006 (structure data deposition date)
AuthorsIm, H. / Manolopoulou, M. / Malito, E. / Shen, Y. / Zhao, J. / Neant-Fery, M. / Sun, C.-Y. / Meredith, S.C. / Sisodia, S.S. / Leissring, M.A. / Tang, W.J.
External linksJ. Biol. Chem. / PubMed:17613531
MethodsX-ray diffraction
Resolution2.8 - 3 Å
Structure data

PDB-2jbu:
Crystal structure of human insulin degrading enzyme complexed with co- purified peptides.
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-2jg4:
Substrate-free IDE structure in its closed conformation
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-DIO:
1,4-DIETHYLENE DIOXIDE

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
  • escherichia coli (E. coli)
KeywordsHYDROLASE / METAL-BINDING / METALLOPROTEASE / ZINC / PROTEASE / ENZYME ASSAY / INSULIN DEGRADING ENZYME

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