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TitleCrystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.
Journal, issue, pagesScience, Vol. 317, Page 510-512, Year 2007
Publish dateJun 7, 2007 (structure data deposition date)
AuthorsFerguson, A.D. / McKeever, B.M. / Xu, S. / Wisniewski, D. / Miller, D.K. / Yamin, T.T. / Spencer, R.H. / Chu, L. / Ujjainwalla, F. / Cunningham, B.R. ...Ferguson, A.D. / McKeever, B.M. / Xu, S. / Wisniewski, D. / Miller, D.K. / Yamin, T.T. / Spencer, R.H. / Chu, L. / Ujjainwalla, F. / Cunningham, B.R. / Evans, J.F. / Becker, J.W.
External linksScience / PubMed:17600184
MethodsX-ray diffraction
Resolution4 - 4.25 Å
Structure data

PDB-2q7m:
Crystal structure of human FLAP with MK-591
Method: X-RAY DIFFRACTION / Resolution: 4.25 Å

PDB-2q7r:
Crystal structure of human FLAP with an iodinated analog of MK-591
Method: X-RAY DIFFRACTION / Resolution: 4 Å

Chemicals

ChemComp-2CS:
3-[3-(TERT-BUTYLTHIO)-1-(4-CHLOROBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID

ChemComp-3CS:
3-[3-(3,3-DIMETHYLBUTANOYL)-1-(4-IODOBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / LIPID TRANSPORT / MAPEG / FLAP

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