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-Structure paper
Title | Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors |
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Journal, issue, pages | Chem. Biol. Drug Des., Vol. 69, Page 444-450, Year 2007 |
Publish date | May 3, 2007 (structure data deposition date) |
![]() | Van Huis, C.A. / Bigge, C.F. / Casimiro-Garcia, A. / Cody, W.L. / Dudley, D.A. / Filipski, K.J. / Heemstra, R.J. / Kohrt, J.T. / Narasimhan, L.S. / Schaum, R.P. ...Van Huis, C.A. / Bigge, C.F. / Casimiro-Garcia, A. / Cody, W.L. / Dudley, D.A. / Filipski, K.J. / Heemstra, R.J. / Kohrt, J.T. / Narasimhan, L.S. / Schaum, R.P. / Zhang, E. / Bryant, J.W. / Haarer, S. / Janiczek, N. / Leadley, R.J. / McClanahan, T. / Thomas Peterson, J. / Welch, K.M. / Edmunds, J.J. |
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Methods | X-ray diffraction |
Resolution | 1.5 Å |
Structure data | ![]() PDB-2pr3: |
Chemicals | ![]() ChemComp-CA: ![]() ChemComp-237: ![]() ChemComp-HOH: |
Source |
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![]() | BLOOD CLOTTING / FXA COAGULATION FACTOR INHIBITOR |