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Structure paper

TitleStructural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 Disease
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 23525-23531, Year 2007
Publish dateJul 3, 2006 (structure data deposition date)
AuthorsXu, S. / Benoff, B. / Liou, H.-L. / Lobel, P. / Stock, A.M.
External linksJ. Biol. Chem. / PubMed:17573352
MethodsX-ray diffraction
Resolution1.81 Å
Structure data

PDB-2hka:
Crystal structure of bovine NPC2 and cholesterol sulfate complex
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ACT:
ACETATE ION

ChemComp-SO4:
SULFATE ION

ChemComp-C3S:
CHOLEST-5-EN-3-YL HYDROGEN SULFATE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • bos taurus (domestic cattle)
KeywordsLIPID BINDING PROTEIN / BETA BARREL

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