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Structure paper

TitleAsparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 24027-24038, Year 2007
Publish dateJun 19, 2007 (structure data deposition date)
AuthorsColeman, M.L. / McDonough, M.A. / Hewitson, K.S. / Coles, C. / Mecinovic, J. / Edelmann, M. / Cook, K.M. / Cockman, M.E. / Lancaster, D.E. / Kessler, B.M. ...Coleman, M.L. / McDonough, M.A. / Hewitson, K.S. / Coles, C. / Mecinovic, J. / Edelmann, M. / Cook, K.M. / Cockman, M.E. / Lancaster, D.E. / Kessler, B.M. / Oldham, N.J. / Ratcliffe, P.J. / Schofield, C.J.
External linksJ. Biol. Chem. / PubMed:17573339
MethodsX-ray diffraction
Resolution2.35 - 2.6 Å
Structure data

PDB-2qc9:
Mouse Notch 1 Ankyrin Repeat Intracellular Domain
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-3p3n:
Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1930-1949) peptide
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3p3p:
Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1997-2016) peptide
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-FE2:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsTRANSCRIPTION / beta-hydroxy asparagine / ankyrin repeat / factor inhibiting HIF / OXIDOREDUCTASE/TRANSCRIPTION / Double Stranded Beta-Helix / hydroxylase / Iron binding / 2-oxoglutarate binding / Hypoxia Inducible Factor binding / Ankyrin Repeat domain binding / OXIDOREDUCTASE-TRANSCRIPTION complex

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