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Structure paper

TitleCrystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.
Journal, issue, pagesScience, Vol. 316, Page 1632-1634, Year 2007
Publish dateDec 19, 2006 (structure data deposition date)
AuthorsOhto, U. / Fukase, K. / Miyake, K. / Satow, Y.
External linksScience / PubMed:17569869
MethodsX-ray diffraction
Resolution2 - 2.21 Å
Structure data

PDB-2e56:
Crystal structure of human MD-2
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2e59:
Crystal structure of human MD-2 in complex with lipid IVa
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MYR:
MYRISTIC ACID

ChemComp-HOH:
WATER

ChemComp-LP5:
(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE

ChemComp-LP4:
2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-4-O-phosphono-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsLIPID BINDING PROTEIN / INNATE IMMUNITY / LIPID-BINDING

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