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Structure paper

TitleStructural basis of spirolactone recognition by the mineralocorticoid receptor
Journal, issue, pagesMol. Pharmacol., Vol. 72, Page 563-571, Year 2007
Publish dateDec 18, 2006 (structure data deposition date)
AuthorsHuyet, J. / Pinon, G.M. / Fay, M.R. / Fagart, J. / Rafestin-Oblin, M.E.
External linksMol. Pharmacol. / PubMed:17569793
MethodsX-ray diffraction
Resolution2.29 Å
Structure data

PDB-2oax:
Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420
Method: X-RAY DIFFRACTION / Resolution: 2.29 Å

Chemicals

ChemComp-SNL:
SPIRONOLACTONE / medication*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / ALDOSTERONE; STEROID RECEPTOR; NUCLEAR RECEPTOR; TRANSCRIPTION FACTOR; ACTIVATING MUTATION / HYPERTENSION; ANTAGONIST; SPIRONOLACTONE

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