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Structure paper

TitleStructural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 129, Page 735-746, Year 2007
Publish dateFeb 26, 2007 (structure data deposition date)
AuthorsDeindl, S. / Kadlecek, T.A. / Brdicka, T. / Cao, X. / Weiss, A. / Kuriyan, J.
External linksCell(Cambridge,Mass. ) / PubMed:17512407
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-2ozo:
Autoinhibited intact human ZAP-70
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Inactive ZAP-70 / tandem SH2 / Autoinhibition / ITAM / hydrogen bonding network / TCR signaling

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