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-Structure paper
Title | Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 17, Page 3562-3569, Year 2007 |
Publish date | Apr 6, 2007 (structure data deposition date) |
Authors | Pinkerton, A.B. / Lee, T.T. / Hoffman, T.Z. / Wang, Y. / Kahraman, M. / Cook, T.G. / Severance, D. / Gahman, T.C. / Noble, S.A. / Shiau, A.K. / Davis, R.L. |
External links | Bioorg. Med. Chem. Lett. / PubMed:17498954 |
Methods | X-ray diffraction |
Resolution | 1.849 - 2.11 Å |
Structure data | PDB-2pg2: PDB-2uyi: PDB-2uym: |
Chemicals | ChemComp-MG: ChemComp-ADP: ChemComp-K01: ChemComp-HOH: ChemComp-K02: ChemComp-K03: |
Source |
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Keywords | MOTOR PROTEIN / CELL CYCLE / kinesin spindle protein; KSP; Eg5; complex; inhibitor; thiophene / KSP / EG5 / COMPLEX / MITOSIS / THIOPHENE / INHIBITOR / NUCLEOTIDE-BINDING / KINESIN SPINDLE PROTEIN / CELL DIVISION / PHOSPHORYLATION / MICROTUBULE / COILED COIL / ATP-BINDING |