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Structure paper

TitleMechanism for expanding the decoding capacity of transfer RNAs by modification of uridines.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 14, Page 498-502, Year 2007
Publish dateMar 1, 2007 (structure data deposition date)
AuthorsWeixlbaumer, A. / Murphy 4th., F.V. / Dziergowska, A. / Malkiewicz, A. / Vendeix, F.A. / Agris, P.F. / Ramakrishnan, V.
External linksNat. Struct. Mol. Biol. / PubMed:17496902
MethodsX-ray diffraction
Resolution2.8 - 3.1 Å
Structure data

PDB-2uu9:
Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUG-codon in the A-site and paromomycin.
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-2uua:
Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUC-codon in the A-site and paromomycin.
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-2uub:
Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUU-codon in the A-site and paromomycin.
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2uuc:
Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUA-codon in the A-site and paromomycin.
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-PAR:
PAROMOMYCIN / medication*YM

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-ZN:
Unknown entry

Source
  • thermus thermophilus (bacteria)
  • synthetic construct (others)
KeywordsRIBOSOME / TRNA-BINDING / RRNA-BINDING / METAL-BINDING / ZINC-FINGER / TRANSLATION / COILED COIL / PAROMOMYCIN / TRNA / ZINC / MRNA / CMO5U / RNA-BINDING / MODIFIACTIONS / RIBOSOMAL PROTEIN / RIBONUCLEOPROTEIN / MODIFICATIONS / DECODING

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