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TitleGalanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors.
Journal, issue, pagesJ. Mol. Biol., Vol. 369, Page 895-901, Year 2007
Publish dateApr 10, 2007 (structure data deposition date)
AuthorsHansen, S.B. / Taylor, P.
External linksJ. Mol. Biol. / PubMed:17481657
MethodsX-ray diffraction
Resolution1.76 - 2.88 Å
Structure data

PDB-2pgz:
Crystal structure of Cocaine bound to an ACh-Binding Protein
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-2ph9:
Galanthamine bound to an ACh-binding Protein
Method: X-RAY DIFFRACTION / Resolution: 2.88 Å

Chemicals

ChemComp-COC:
COCAINE / alkaloid*YM

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-GNT:
(-)-GALANTHAMINE / inhibitor, alkaloid*YM

Source
  • aplysia californica (California sea hare)
KeywordsCHOLINE-BINDING PROTEIN / non-competitive inhibitors / nicotinic acetycholine receptors / acetycholine-binding protein / benzodiazepine / galanthamine / cocaine / CHOLINE BINDING PROTEIN / nicotinic acetylcholine receptor / acetylcholine-binding protein

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