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TitlePyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2).
Journal, issue, pagesJ. Med. Chem., Vol. 50, Page 2647-2654, Year 2007
Publish dateMar 8, 2007 (structure data deposition date)
AuthorsAnderson, D.R. / Meyers, M.J. / Vernier, W.F. / Mahoney, M.W. / Kurumbail, R.G. / Caspers, N. / Poda, G.I. / Schindler, J.F. / Reitz, D.B. / Mourey, R.J.
External linksJ. Med. Chem. / PubMed:17480064
MethodsX-ray diffraction
Resolution3.8 Å
Structure data

PDB-2p3g:
Crystal structure of a pyrrolopyridine inhibitor bound to MAPKAP Kinase-2
Method: X-RAY DIFFRACTION / Resolution: 3.8 Å

Chemicals

ChemComp-F10:
2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase domain / ATP-binding / serine/threonine kinase / MAP kinases / MK-2 / MK2

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