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-Structure paper
Title | Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 129, Page 6388-6389, Year 2007 |
Publish date | Apr 10, 2007 (structure data deposition date) |
Authors | Di Costanzo, L. / Pique, M.E. / Christianson, D.W. |
External links | J. Am. Chem. Soc. / PubMed:17469833 |
Methods | X-ray diffraction |
Resolution | 1.7 - 1.95 Å |
Structure data | PDB-2pha: PDB-2pho: PDB-2zav: |
Chemicals | ChemComp-MN: ChemComp-HOH: ChemComp-TSZ: |
Source |
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Keywords | HYDROLASE / PROTON WIRE / THIOSEMICARBAZIDE / FRAGMENT / INHIBITOR DESIGN / Manganese cluster coordination / apical water / Alternative splicing / Arginine metabolism / Cytoplasm / Disease mutation / Metal-binding / Phosphorylation / Polymorphism / Urea cycle |