タイトル | Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B Through Structure-Based Design |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 50, Page 2289-, Year 2007 |
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掲載日 | 2007年3月15日 (構造データの登録日) |
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著者 | Donald, A. / Mchardy, T. / Rowlands, M.G. / Hunter, L.J. / Davies, T.G. / Berdini, V. / Boyle, R.G. / Aherne, G.W. / Garrett, M.D. / Collins, I. |
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リンク | J. Med. Chem. / PubMed:17451235 |
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手法 | X線回折 |
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解像度 | 1.94 - 2 Å |
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構造データ | PDB-2uvx: Structure of PKA-PKB chimera complexed with 7-azaindole 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2uvy: Structure of PKA-PKB chimera complexed with methyl-(4-(9H-purin-6-yl)- benzyl)-amine 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-2uvz: Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-2uw0: Structure of PKA-PKB chimera complexed with 6-(4-(4-(4-Chloro-phenyl) -piperidin-4-yl)-phenyl)-9H-purine 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å |
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化合物 | ChemComp-GVI: N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
ChemComp-GVJ: (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
ChemComp-GVK: 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
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由来 | ![](img/tx_mammal.gif) ![](data/taxo/icon/Bos_taurus_S.png) bos taurus (ウシ)![](img/tx_human.gif) homo sapiens (ヒト)
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キーワード | TRANSFERASE/INHIBITOR / CAMP (CAMP) / KINASE (キナーゼ) / MYRISTATE (ミリスチン酸) / TRANSFERASE (転移酵素) / LIPOPROTEIN (リポタンパク質) / SERINE/THREONINE-PROTEIN KINASE / TRANSFERASE-INHIBITOR COMPLEX / NUCLEOTIDE-BINDING / PROTEIN KINASE INHIBITOR / ATP- BINDING / NUCLEAR PROTEIN / PHOSPHORYLATION (リン酸化) / ATP-BINDING |
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