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Title | Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. |
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Journal, issue, pages | J. Med. Chem., Vol. 50, Page 2399-2407, Year 2007 |
Publish date | Mar 12, 2007 (structure data deposition date) |
Authors | Ghosh, A.K. / Kumaragurubaran, N. / Hong, L. / Kulkarni, S.S. / Xu, X. / Chang, W. / Weerasena, V. / Turner, R. / Koelsch, G. / Bilcer, G. / Tang, J. |
External links | J. Med. Chem. / PubMed:17432843 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-2p4j: |
Chemicals | ChemComp-23I: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / beta-secretase / memapsin / BACE / asp / aspartic protease / acid protease / Alzheimer's disease / drug design / structure based drug design |