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-Structure paper
Title | Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. |
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Journal, issue, pages | Mol. Cancer Ther., Vol. 6, Page 1198-1211, Year 2007 |
Publish date | Mar 20, 2007 (structure data deposition date) |
![]() | Sharp, S.Y. / Prodromou, C. / Boxall, K. / Powers, M.V. / Holmes, J.L. / Box, G. / Matthews, T.P. / Cheung, K.M. / Kalusa, A. / James, K. ...Sharp, S.Y. / Prodromou, C. / Boxall, K. / Powers, M.V. / Holmes, J.L. / Box, G. / Matthews, T.P. / Cheung, K.M. / Kalusa, A. / James, K. / Hayes, A. / Hardcastle, A. / Dymock, B. / Brough, P.A. / Barril, X. / Cansfield, J.E. / Wright, L. / Surgenor, A. / Foloppe, N. / Hubbard, R.E. / Aherne, W. / Pearl, L. / Jones, K. / McDonald, E. / Raynaud, F. / Eccles, S. / Drysdale, M. / Workman, P. |
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Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | ![]() PDB-2uwd: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-SO4: ![]() ChemComp-2GG: ![]() ChemComp-HOH: |
Source |
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![]() | CHAPERONE / HEAT SHOCK / ATP-BINDING / PHOSPHORYLATION / NUCLEOTIDE-BINDING |