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Structure paper

TitleStructural basis of na+ activation mimicry in murine thrombin.
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 16355-16361, Year 2007
Publish dateDec 21, 2006 (structure data deposition date)
AuthorsMarino, F. / Chen, Z.W. / Ergenekan, C.E. / Bush-Pelc, L.A. / Mathews, F.S. / Di Cera, E.
External linksJ. Biol. Chem. / PubMed:17428793
MethodsX-ray diffraction
Resolution1.75 - 2.2 Å
Structure data

PDB-2ocv:
Structural basis of Na+ activation mimicry in murine thrombin
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2od3:
Human thrombin chimera with human residues 184a, 186, 186a, 186b, 186c and 222 replaced by murine thrombin equivalents.
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-0G6:
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsHYDROLASE / SERINE PROTEASE / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex

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