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Structure paper

TitleCrystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 Fc reveals a novel epitope and evidence for affinity maturation.
Journal, issue, pagesJ. Mol. Biol., Vol. 368, Page 1321-1331, Year 2007
Publish dateSep 28, 2006 (structure data deposition date)
AuthorsDuquerroy, S. / Stura, E.A. / Bressanelli, S. / Fabiane, S.M. / Vaney, M.C. / Beale, D. / Hamon, M. / Casali, P. / Rey, F.A. / Sutton, B.J. / Taussig, M.J.
External linksJ. Mol. Biol. / PubMed:17395205
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-2j6e:
Crystal Structure of an Autoimmune Complex between a Human IgM Rheumatoid Factor and IgG1 Fc reveals a Novel Fc Epitope and Evidence for Affinity Maturation
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-CD:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-CAC:
CACODYLATE ION

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / AUTOIMMUNE COMPLEX HUMAN IGM RHEUMATOID FACTOR IGG1-FC / IMMUNOGLOBULIN C REGION / MEMBRANE / GLYCOPROTEIN / TRANSMEMBRANE / HYPOTHETICAL PROTEIN / IMMUNOGLOBULIN DOMAIN

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