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TitleDiscovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
Journal, issue, pagesJ. Med. Chem., Vol. 50, Page 1727-1730, Year 2007
Publish dateJul 31, 2006 (structure data deposition date)
AuthorsGreco, M.N. / Hawkins, M.J. / Powell, E.T. / Almond, H.R. / de Garavilla, L. / Hall, J. / Minor, L.K. / Wang, Y. / Corcoran, T.W. / Di Cera, E. ...Greco, M.N. / Hawkins, M.J. / Powell, E.T. / Almond, H.R. / de Garavilla, L. / Hall, J. / Minor, L.K. / Wang, Y. / Corcoran, T.W. / Di Cera, E. / Cantwell, A.M. / Savvides, S.N. / Damiano, B.P. / Maryanoff, B.E.
External linksJ. Med. Chem. / PubMed:17361995
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-2hvx:
Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase by Using Structure-Based Drug Design
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-DRX:
[(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / serine protease

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