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Structure paper

TitleA structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.
Journal, issue, pagesMol. Endocrinol., Vol. 21, Page 1066-1081, Year 2007
Publish dateFeb 13, 2007 (structure data deposition date)
AuthorsMadauss, K.P. / Grygielko, E.T. / Deng, S.J. / Sulpizio, A.C. / Stanley, T.B. / Wu, C. / Short, S.A. / Thompson, S.K. / Stewart, E.L. / Laping, N.J. ...Madauss, K.P. / Grygielko, E.T. / Deng, S.J. / Sulpizio, A.C. / Stanley, T.B. / Wu, C. / Short, S.A. / Thompson, S.K. / Stewart, E.L. / Laping, N.J. / Williams, S.P. / Bray, J.D.
External linksMol. Endocrinol. / PubMed:17356170
MethodsX-ray diffraction
Resolution2 - 2.6 Å
Structure data

PDB-2ovh:
Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2ovm:
Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor NCoR
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-AS0:
4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Progesterone receptor / PR / Nuclear Receptor / Steroid Receptor / Co-Repressor / Asoprisnil / NCoR

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