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Structure paper

Titlec-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty.
Journal, issue, pagesStructure, Vol. 15, Page 299-311, Year 2007
Publish dateJan 11, 2007 (structure data deposition date)
AuthorsSeeliger, M.A. / Nagar, B. / Frank, F. / Cao, X. / Henderson, M.N. / Kuriyan, J.
External linksStructure / PubMed:17355866
MethodsX-ray diffraction
Resolution2.07 Å
Structure data

PDB-2oiq:
Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

Chemicals

ChemComp-STI:
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE / medication, inhibitor*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
KeywordsTRANSFERASE / SRC / kinase / imatinib / inactive

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