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TitleFluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.
Journal, issue, pagesNat. Chem. Biol., Vol. 3, Page 222-228, Year 2007
Publish dateOct 12, 2006 (structure data deposition date)
AuthorsVenkatraman, P. / Nguyen, T.T. / Sainlos, M. / Bilsel, O. / Chitta, S. / Imperiali, B. / Stern, L.J.
External linksNat. Chem. Biol. / PubMed:17351628
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-2ipk:
Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • staphylococcus aureus subsp. aureus mu50 (bacteria)
  • influenza a virus
KeywordsIMMUNE SYSTEM / HLA / DR1 / MHC / Major Histocompatibility Complex / Fluorogenic Probe / SEC3 / 4-(N / N-dimethylamino)phthalimidoalanyl / DAPA

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