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TitleNovel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 2863-2868, Year 2007
Publish dateFeb 15, 2007 (structure data deposition date)
AuthorsZhang, H.C. / Bonaga, L.V. / Ye, H. / Derian, C.K. / Damiano, B.P. / Maryanoff, B.E.
External linksBioorg. Med. Chem. Lett. / PubMed:17350261
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-2ow3:
Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-BIM:
BIS-(INDOLE)MALEIMIDE PYRIDINOPHANE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase-inhibitor complex

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