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TitleDiscovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 2317-2321, Year 2007
Publish dateJan 12, 2007 (structure data deposition date)
AuthorsVelaparthi, U. / Wittman, M. / Liu, P. / Stoffan, K. / Zimmermann, K. / Sang, X. / Carboni, J. / Li, A. / Attar, R. / Gottardis, M. ...Velaparthi, U. / Wittman, M. / Liu, P. / Stoffan, K. / Zimmermann, K. / Sang, X. / Carboni, J. / Li, A. / Attar, R. / Gottardis, M. / Greer, A. / Chang, C.Y. / Jacobsen, B.L. / Sack, J.S. / Sun, Y. / Langley, D.R. / Balasubramanian, B. / Vyas, D.
External linksBioorg. Med. Chem. Lett. / PubMed:17317169
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2oj9:
Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-BMI:
3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / HORMONE/GROWTH FACTOR / IGF-1R / KINASE DOMAIN

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