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TitlePhosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 2210-2215, Year 2007
Publish dateOct 19, 2006 (structure data deposition date)
AuthorsTemperini, C. / Innocenti, A. / Guerri, A. / Scozzafava, A. / Rusconi, S. / Supuran, C.T.
External linksBioorg. Med. Chem. Lett. / PubMed:17314045
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2it4:
X ray structure of the complex between Carbonic Anhydrase I and the phosphonate antiviral drug foscarnet
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PPF:
PHOSPHONOFORMIC ACID / medication, antivirus, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE / carbonic anhydrase / antiviral / crystal stucture

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