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Structure paper

TitleStructural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors.
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 10449-, Year 2007
Publish dateJan 29, 2007 (structure data deposition date)
AuthorsHeldring, N. / Pawson, T. / Mcdonnell, D. / Treuter, E. / Gustafsson, J.A. / Pike, A.C.W.
External linksJ. Biol. Chem. / PubMed:17283072
MethodsX-ray diffraction
Resolution2.1 - 2.55 Å
Structure data

PDB-2jf9:
ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A TAMOXIFEN-SPECIFIC PEPTIDE ANTAGONIST
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2jfa:
ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH AN AFFINITY-SELECTED COREPRESSOR PEPTIDE
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-OHT:
4-HYDROXYTAMOXIFEN

ChemComp-BCT:
BICARBONATE ION / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-RAL:
RALOXIFENE / medication*YM

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / TRANSCRIPTION FACTOR / LIPID-BINDING / TRANSCRIPTION REGULATION / LIGAND-BINDING DOMAIN (LBD) / RECEPTOR / ZINC-FINGER / DNA-BINDING / STEROID-BINDING / NUCLEAR RECEPTOR / PEPTIDE ANTAGONIST / METAL-BINDING / NUCLEAR PROTEIN / PHOSPHORYLATION / PHAGE DISPLAY / COREPRESSOR / STEROID- BINDING

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