EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases.
ジャーナル・号・ページ	J. Am. Chem. Soc., Vol. 129, Page 2466-2475, Year 2007
掲載日	2008年10月27日 (構造データの登録日)
著者	Bertini, I. / Calderone, V. / Fragai, M. / Giachetti, A. / Loconte, M. / Luchinat, C. / Maletta, M. / Nativi, C. / Yeo, K.J.
リンク	J. Am. Chem. Soc. / PubMed:17269766
手法	X線回折
解像度	1.1 - 1.8 Å
構造データ	PDB-3f15: Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor (S)-N-(2,3-dihydroxypropyl)-4-methoxy-N-(2-nitroso-2-oxoethyl)benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3f16: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor (R)-N-(3-hydroxy-1-nitroso-1-oxopropan-2-yl)-4-methoxybenzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.16 Å PDB-3f17: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-(2-nitroso-2-oxoethyl)biphenyl-4-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.1 Å PDB-3f18: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor 4-fluoro-N-(2-hydroxyethyl)-N-(2-nitroso-2-oxoethyl)benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.13 Å PDB-3f19: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor 4-fluoro-N-(2-nitroso-2-oxoethyl)benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.13 Å PDB-3f1a: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-(2-nitroso-2-oxoethyl)benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-3lk8: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor paramethoxy-sulfonyl-glycine hydroxamate 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3nx7: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-Hydroxy-2-(N-(2-hydroxyethyl)4-methoxyphenylsulfonamido)acetamide 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-CA: Unknown entry / カルシウムジカチオン ChemComp-HS1: 2-[[(2S)-2,3-dihydroxypropyl]-(4-methoxyphenyl)sulfonyl-amino]-N-oxo-ethanamide ChemComp-HOH: WATER ChemComp-HS3: (2R)-3-hydroxy-2-[(4-methoxyphenyl)sulfonylamino]-N-oxo-propanamide ChemComp-HS4: N-oxidanyl-2-[(4-phenylphenyl)sulfonylamino]ethanamide ChemComp-HS5: 2-[(4-fluorophenyl)sulfonyl-(2-hydroxyethyl)amino]-N-oxo-ethanamide ChemComp-HS6: 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide ChemComp-HS7: N-oxo-2-(phenylsulfonylamino)ethanamide ChemComp-Z79: N-hydroxy-N~2~-[(4-methoxyphenyl)sulfonyl]glycinamide / (4-メトキシフェニルスルホニルアミノ)アセトヒドロキシム酸 ChemComp-NHK: N-hydroxy-N~2~-(2-hydroxyethyl)-N~2~-[(4-methoxyphenyl)sulfonyl]glycinamide
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / MATRIX METALLOPROTEINASE / MMP12 / ELASTASE / COMPLEX (ELASTASE-INHIBITOR) / METALLO ELASTASE / CALCIUM / EXTRACELLULAR MATRIX / GLYCOPROTEIN / METAL-BINDING / METALLOPROTEASE / POLYMORPHISM / PROTEASE / SECRETED / ZINC / Zymogen / ELASTASE INHIBITOR