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-Structure paper
Title | Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate. |
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Journal, issue, pages | J. Med. Chem., Vol. 50, Page 897-, Year 2007 |
Publish date | Dec 18, 2006 (structure data deposition date) |
![]() | Slater, M.J. / Amphlett, E.M. / Andrews, D.M. / Bravi, G. / Burton, G. / Cheasty, A.G. / Corfield, J.A. / Ellis, M.R. / Fenwick, R.H. / Fernandes, S. ...Slater, M.J. / Amphlett, E.M. / Andrews, D.M. / Bravi, G. / Burton, G. / Cheasty, A.G. / Corfield, J.A. / Ellis, M.R. / Fenwick, R.H. / Fernandes, S. / Guidetti, R. / Haigh, D. / Hartley, C.D. / Howes, P.D. / Jackson, D.L. / Jarvest, R.L. / Lovegrove, V.L. / Medhurst, K.J. / Parry, N.R. / Price, H. / Shah, P. / Singh, O.M. / Stocker, R. / Thommes, P. / Wilkinson, C. / Wonacott, A. |
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Methods | X-ray diffraction |
Resolution | 2 - 2.2 Å |
Structure data | ![]() PDB-2jc0: ![]() PDB-2jc1: |
Chemicals | ![]() ChemComp-699: ![]() ChemComp-HOH: ![]() ChemComp-698: |
Source |
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![]() | HYDROLASE / HEPATITIS / POLYMERASE |