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TitleCrystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.
Journal, issue, pagesRetrovirology, Vol. 4, Page 1-1, Year 2007
Publish dateJun 12, 2006 (structure data deposition date)
AuthorsHeaslet, H. / Lin, Y.C. / Tam, K. / Torbett, B.E. / Elder, J.H. / Stout, C.D.
External linksRetrovirology / PubMed:17212810
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-2hah:
The structure of FIV 12S protease in complex with TL-3
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-3TL:
benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate

ChemComp-HOH:
WATER

Source
  • feline immunodeficiency virus (isolate petaluma)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / retroviral / protease / aspartyl / feline / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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