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TitleGene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide.
Journal, issue, pagesAcs Chem. Biol., Vol. 1, Page 176-183, Year 2006
Publish dateMar 4, 2006 (structure data deposition date)
AuthorsXia, J. / Noronha, A. / Toudjarska, I. / Li, F. / Akinc, A. / Braich, R. / Frank-Kamenetsky, M. / Rajeev, K.G. / Egli, M. / Manoharan, M.
External linksAcs Chem. Biol. / PubMed:17163665
MethodsX-ray diffraction
Resolution1.61 Å
Structure data

PDB-2g92:
Crystal Structure Analysis of the RNA Dodecamer CGC-(NF2)-AAUUAGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)
Method: X-RAY DIFFRACTION / Resolution: 1.61 Å

Chemicals

ChemComp-HOH:
WATER

KeywordsRNA / 2 / 4-Difluorotoluyl Nucleoside / Chemical Modification / RNA Interference / Hydrogen Bonding

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