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Structure paper

TitleStructural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase.
Journal, issue, pagesNucleic Acids Res., Vol. 35, Page 186-192, Year 2007
Publish dateOct 25, 2006 (structure data deposition date)
AuthorsSabini, E. / Hazra, S. / Konrad, M. / Burley, S.K. / Lavie, A.
External linksNucleic Acids Res. / PubMed:17158155
MethodsX-ray diffraction
Resolution1.8 - 2.15 Å
Structure data

PDB-2no9:
The structure of deoxycytidine kinase complexed with troxacitabine and ADP.
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-2noa:
The structure of deoxycytidine kinase complexed with lamivudine and ADP.
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-LTT:
4-AMINO-1-[(2S,4S)-2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL]PYRIMIDIN-2(1H)-ONE / anticancer*YM

ChemComp-HOH:
WATER

ChemComp-3TC:
4-AMINO-1-[(2R,5S)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]PYRIMIDIN-2(1H)-ONE / medication, antiretroviral*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / dCK / troxacitabine / human deoxycytidine kinase / L-dC / enantiomer / anticancer / 3TC / antiviral / Lamivudine / Epivir

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