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TitleSlow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.
Journal, issue, pagesBiochem. J., Vol. 402, Page 251-260, Year 2007
Publish dateAug 9, 2006 (structure data deposition date)
AuthorsBateman, R.L. / Ashworth, J. / Witte, J.F. / Baker, L.J. / Bhanumoorthy, P. / Timm, D.E. / Hurley, T.D. / Grompe, M. / McClard, R.W.
External linksBiochem. J. / PubMed:17064256
MethodsX-ray diffraction
Resolution1.35 Å
Structure data

PDB-2hzy:
Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-MN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-NI:
NICKEL (II) ION

ChemComp-DHJ:
4-(2-CARBOXYETHYL)(HYDROXY)PHOSPHORYL]-3-OXOBUTANOIC ACID

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / transition-state mimicking complex

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