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Structure paper

TitleIsothiazoles as active-site inhibitors of HCV NS5B polymerase
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 28-33, Year 2007
Publish dateSep 29, 2006 (structure data deposition date)
AuthorsYan, S. / Appleby, T. / Gunic, E. / Shim, J.H. / Tasu, T. / Kim, H. / Rong, F. / Chen, H. / Hamatake, R. / Wu, J.Z. ...Yan, S. / Appleby, T. / Gunic, E. / Shim, J.H. / Tasu, T. / Kim, H. / Rong, F. / Chen, H. / Hamatake, R. / Wu, J.Z. / Hong, Z. / Yao, N.
External linksBioorg. Med. Chem. Lett. / PubMed:17049853
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2ijn:
Isothiazoles as active-site inhibitors of HCV NS5B polymerase
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-221:
(2R,3R)-3-{[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO}-2-CYANO-3-THIOXOPROPANAMIDE

ChemComp-HOH:
WATER

Source
  • hepatitis c virus subtype 1b
KeywordsTRANSCRIPTION / TRANSFERASE / HCV; NS5B; Viral RNA directed RNA polymerase; RDRP; active site; covalent inhibitor

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