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-Structure paper
Title | Isothiazoles as active-site inhibitors of HCV NS5B polymerase |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 17, Page 28-33, Year 2007 |
Publish date | Sep 29, 2006 (structure data deposition date) |
![]() | Yan, S. / Appleby, T. / Gunic, E. / Shim, J.H. / Tasu, T. / Kim, H. / Rong, F. / Chen, H. / Hamatake, R. / Wu, J.Z. ...Yan, S. / Appleby, T. / Gunic, E. / Shim, J.H. / Tasu, T. / Kim, H. / Rong, F. / Chen, H. / Hamatake, R. / Wu, J.Z. / Hong, Z. / Yao, N. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.2 Å |
Structure data | ![]() PDB-2ijn: |
Chemicals | ![]() ChemComp-221: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSCRIPTION / TRANSFERASE / HCV; NS5B; Viral RNA directed RNA polymerase; RDRP; active site; covalent inhibitor |