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TitleNovel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 63-67, Year 2007
Publish dateAug 14, 2006 (structure data deposition date)
AuthorsYan, S. / Larson, G. / Wu, J.Z. / Appleby, T. / Ding, Y. / Hamatake, R. / Hong, Z. / Yao, N.
External linksBioorg. Med. Chem. Lett. / PubMed:17049849
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2i1r:
Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-VXR:
(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-2-{[(S)-(4-FLUOROPHENYL)(1H-TETRAZOL-5-YL)METHYL]AMINO}-1,3-THIAZOL-4(5H)-ONE

ChemComp-HOH:
WATER

Source
  • hepatitis c virus
KeywordsTRANSFERASE / hcv / ns5b / viral RNA-directed RNA Polymerase / RdRP / allosteric inhibitor / HCV inhibitor complex

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