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Title | Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes. |
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Journal, issue, pages | J. Med. Chem., Vol. 49, Page 6416-6420, Year 2006 |
Publish date | Aug 9, 2006 (structure data deposition date) |
Authors | Madar, D.J. / Kopecka, H. / Pireh, D. / Yong, H. / Pei, Z. / Li, X. / Wiedeman, P.E. / Djuric, S.W. / Von Geldern, T.W. / Fickes, M.G. ...Madar, D.J. / Kopecka, H. / Pireh, D. / Yong, H. / Pei, Z. / Li, X. / Wiedeman, P.E. / Djuric, S.W. / Von Geldern, T.W. / Fickes, M.G. / Bhagavatula, L. / McDermott, T. / Wittenberger, S. / Richards, S.J. / Longenecker, K.L. / Stewart, K.D. / Lubben, T.H. / Ballaron, S.J. / Stashko, M.A. / Long, M.A. / Wells, H. / Zinker, B.A. / Mika, A.K. / Beno, D.W. / Kempf-Grote, A.J. / Polakowski, J. / Segreti, J. / Reinhart, G.A. / Fryer, R.M. / Sham, H.L. / Trevillyan, J.M. |
External links | J. Med. Chem. / PubMed:17034148 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-2i03: |
Chemicals | ChemComp-AXD: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / enzyme / serine peptidase |