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TitlePharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.
Journal, issue, pagesEndocrinology, Vol. 148, Page 4-12, Year 2007
Publish dateNov 14, 2006 (structure data deposition date)
AuthorsOstrowski, J. / Kuhns, J.E. / Lupisella, J.A. / Manfredi, M.C. / Beehler, B.C. / Krystek, S.R. / Bi, Y. / Sun, C. / Seethala, R. / Golla, R. ...Ostrowski, J. / Kuhns, J.E. / Lupisella, J.A. / Manfredi, M.C. / Beehler, B.C. / Krystek, S.R. / Bi, Y. / Sun, C. / Seethala, R. / Golla, R. / Sleph, P.G. / Fura, A. / An, Y. / Kish, K.F. / Sack, J.S. / Mookhtiar, K.A. / Grover, G.J. / Hamann, L.G.
External linksEndocrinology / PubMed:17008401
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-2nw4:
Crystal Structure of the Rat Androgen Receptor Ligand Binding Domain Complex with BMS-564929
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-8NH:
2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsHORMONE/GROWTH FACTOR / ANDROGEN RECEPTOR / STEROID RECEPTOR / NUCLEAR RECEPTOR / TRANSCRIPTION REGULATION / LIGAND-BINDING DOMAIN / HORMONE-GROWTH FACTOR COMPLEX

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