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TitleThe development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 5973-5977, Year 2006
Publish dateJul 3, 2006 (structure data deposition date)
AuthorsSabat, M. / VanRens, J.C. / Laufersweiler, M.J. / Brugel, T.A. / Maier, J. / Golebiowski, A. / De, B. / Easwaran, V. / Hsieh, L.C. / Walter, R.L. ...Sabat, M. / VanRens, J.C. / Laufersweiler, M.J. / Brugel, T.A. / Maier, J. / Golebiowski, A. / De, B. / Easwaran, V. / Hsieh, L.C. / Walter, R.L. / Mekel, M.J. / Evdokimov, A. / Janusz, M.J.
External linksBioorg. Med. Chem. Lett. / PubMed:16997556
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2hk5:
Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-1BM:
3-{[2-(1H-BENZIMIDAZOL-1-YL)-6-{[2-(DIETHYLAMINO)ETHYL]AMINO}PYRIMIDIN-4-YL]AMINO}-4-METHYLPHENOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Hck / Src-family / Kinase Domain

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