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Title3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 6049-6053, Year 2006
Publish dateJul 14, 2006 (structure data deposition date)
AuthorsFraley, M.E. / Steen, J.T. / Brnardic, E.J. / Arrington, K.L. / Spencer, K.L. / Hanney, B.A. / Kim, Y. / Hartman, G.D. / Stirdivant, S.M. / Drakas, B.A. ...Fraley, M.E. / Steen, J.T. / Brnardic, E.J. / Arrington, K.L. / Spencer, K.L. / Hanney, B.A. / Kim, Y. / Hartman, G.D. / Stirdivant, S.M. / Drakas, B.A. / Rickert, K. / Walsh, E.S. / Hamilton, K. / Buser, C.A. / Hardwick, J. / Tao, W. / Beck, S.C. / Mao, X. / Lobell, R.B. / Sepp-Lorenzino, L. / Yan, Y. / Ikuta, M. / Munshi, S.K. / Kuo, L.C. / Kreatsoulas, C.
External linksBioorg. Med. Chem. Lett. / PubMed:16978863
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2hog:
crystal structure of Chek1 in complex with inhibitor 20
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-710:
(5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Chek1 / kinase / cell cycle checkpoint

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